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Abstract #5024

Single Shot Diffusion Trace Spectroscopic Imaging using Radial Echo Planar Trajectories

Andres Saucedo1,2 and M. Albert Thomas1,2
1Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 2Physics and Biology in Medicine Interdepartmental Graduate Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, Spectroscopy, Spectroscopic ImagingWe present the first demonstration of single shot diffusion trace spectroscopic imaging using radial echo planar k-space trajectories on a clinical 3T scanner. Conventional DW-MRS requires three separate acquisitions to compute the trace apparent diffusion coefficient (ADC), whereas the single shot technique generates a trace-weighted signal in one measurement, although this has so far only been applied in NMR and to a limited extent in DW-MRI. Our preliminary results indicate good agreement with expected trace ADC values both in phantom and in healthy brain, showing a promising approach for determining the orientation-independent trace ADC value with non-Cartesian diffusion-weighted spectroscopic imaging.

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