Keywords: Machine Learning/Artificial Intelligence, Neuroinflammation, PET, image synthesisChronic pain-related biomarkers can be found using a specific binding radiotracer called [11C]PBR28 able to target the translocator protein (TSPO), whose expression is increased in activated glia and can be considered as a biomarker for neuroinflammation. One of the main drawbacks of PET imaging is radiation exposure, for which we attempted to develop a deep learning model able to synthesize PET images of the brain from T1w MRI only. Our model produces synthetic TSPO-PET images from T1W MRI which are statistically indistinguishable from the original PET images both on a voxel-wise and on a ROI-wise level.
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