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Abstract #5036

Synthetic CT generation from different MR contrast inputs and evaluation of its quantitative accuracy

Sandeep Kaushik1,2, Cristina Cozzini1, Jonathan J Wyatt3, Hazel McCallum3, Ross Maxwell4, Bjoern Menze2, and Florian Wiesinger1
1GE Healthcare, Munich, Germany, 2Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland, 3Newcastle University and Northern Centre for Cancer Care, Newcastle upon Tyne, United Kingdom, 4Newcastle University, Newcastle upon Tyne, United Kingdom

Synopsis

Keywords: Machine Learning/Artificial Intelligence, Radiotherapy, Synthetic CT, radiation therapy planning, Multi-task network, deep learningMRI to synthetic CT image conversion is a problem of interest for clinical applications such as MR-radiation therapy planning, PET/MR attenuation correction, MR bone imaging. Many methods proposed for this purpose use different MR inputs. In this work, we compare the sCT generated from different 3D MR inputs, including Zero TE (ZTE), fast spin echo (CUBE), and fast spoiled gradient echo with Dixon-type fat-water separation (LAVA-Flex), using a multi-task deep learning (DL) model. We analyze the qualitative and quantitative accuracy of the generated sCT image from each input and highlight the aspects relevant for different clinical applications.

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Keywords