Abstract #5043
Elevated glutamine levels and activation of astrocytes involved in excessive excitatory neurotransmissions in autism spectrum disorder
Kiwamu Matsuoka1,2, Masaki Oya1,3, Manabu Kubota1,4,5, Junya Fujino3,5, Shisei Tei4,5,6,7, Keisuke Takahata1,8, Kenji Tagai1, Yasuharu Yamamoto1,8, Hitoshi Shimada1,9, Chie Seki1, Takashi Itahashi 5, Yuta Y. Aoki5, Haruhisa Ohta5,10, Ryu-ichiro Hashimoto5,11, Genichi Sugihara3, Takayuki Obata12, Ming-Rong Zhang13, Tetsuya Suhara1, Motoaki Nakamura5,14, Nobumasa Kato5, Yuhei Takado1, Hidehiko Takahashi3,15, and Makoto Higuchi1
1Department of Functional Brain Imaging, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan, 2Department of Psychiatry, Nara Medical University, Kashihara, Japan, 3Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, 4Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5Medical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan, 6Institute of Applied Brain Sciences, Waseda University, Tokorozawa, Japan, 7School of Human and Social Sciences, Tokyo International University, Kawagoe, Japan, 8Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan, 9Center for integrated human brain science, Brain Research Institute, Niigata University, Niigata, Japan, 10Department of Psychiatry, School of Medicine, Showa University, Tokyo, Japan, 11Department of Language Sciences, Graduate School of Humanities, Tokyo Metropolitan University, Tokyo, Japan, 12Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan, 13Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan, 14Kanagawa Psychiatric Center, Yokohama, Japan, 15Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan
Synopsis
Keywords: Psychiatric Disorders, Psychiatric DisordersWe conducted MRS and PET to examine if enhanced excitatory tones occur and correlate with astroglial activations and/or diminished dopaminergic suppression of astrocytic functions in autism spectrum disorder (ASD) cases. MRS revealed elevated glutamate and glutamine levels associated with astroglial activation in ASD versus control anterior cingulate cortex, while there were also inverse correlations between glutamine levels and dopamine D1 receptor availability in this area of both ASD cases and controls. Hence, dopamine transmissions may repress astroglial glutamine synthesis independently of the ASD etiology, while astroglial activation in ASD could elicit augmented glutamate synthesis and consequent excitation of neuronal tones.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
