Abstract #5049

GABA Alterations Associated with Social Cognition Deficits in Youth with Autism Spectrum Disorder Compared to Early-Onset Psychosis

Rhideeta Jalal¹, Aarti Nair¹, Joseph O'Neill², Hector Gutierrez¹, Kristen Laulette³, Mary Rshtouni³, Katherine Karlsgodt³, Carrie E. Bearden², and Brenda Bartnik-Olson⁴

¹Psychology, Loma Linda University, Loma Linda, CA, United States, ²Psychiatry, University of California, Los Angeles, Los Angeles, CA, United States, ³Psychology, University of California, Los Angeles, Los Angeles, CA, United States, ⁴Radiology, Loma Linda University, Loma Linda, CA, United States

Synopsis

Keywords: Psychiatric Disorders, Spectroscopy, Adolecents

Proton magnetic resonance spectroscopy (¹H-MRS) can provide valuable information about cortical activity and metabolite concentrations. Previous research using MRS has found alterations in the concentrations of neurotransmitters in neuropsychiatric disorders, notably in autism spectrum disorder (ASD) and early-onset psychosis (EOP). We used ¹H-MRS to quantify signals associated with neurotransmitters in the dorsal anterior cingulate cortex (dACC), a brain region underlying social cognition, by measuring metabolite concentrations and its relationship to social impairments, in youth with ASD or EOP, and typically developing (TD) youth.

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