Abstract #5050

Evaluation of neurotransmitter profiles in the Auditory Cortex in Children with Autism Spectrum Disorder

Maria Baida¹, Sana Vaziri¹, Marisa Lafontaine¹, Carly Demopoulos^1,2, Yi Li¹, and Yan Li¹

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Psychiatric Disorders, Neuro, SpectroscopyIn this study, we used an automated spectral prescription method that predefined the left and right auditory cortex to compare neurotransmitter concentrations between ASD and typically developing control (TDC) and evaluate their relationship to age, sex, and verbal abilities. We found metabolic differences in GABA+ concentrations between the left and right auditory cortex in TDC and ASD. However, no significance was found between TDC and ASD or between ASD with intact speech and impaired speech.

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