Abstract #5053

A study of AFQ-based method in adolescents with first-episode treatment-naive major depressive disorder

Lingyu Jian^1,2, Junfeng Li³, Kefeng Li⁴, Xiaoyong Zhang⁵, and Min Luo⁶

¹Changzhi Medcal College, Changzhi, China, ²Zigong Fourth People‘s Hospital, Zigong, China, ³Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China, ⁴Centre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao, China, ⁵Clinical Science,Philips Healthcare, Chengdu, China, ⁶Zigong Fourth People‘s Hospital, ZIgong, China

Synopsis

Keywords: Psychiatric Disorders, Diffusion Tensor ImagingThe study is to explore the changes of white matter fiber tracts in adolescents with first-episode treatment-naive depression using a DTI-based AFQ method. Adolescent depression can cause damage to multiple white matter fiber tracts. The severity of depression is positively correlated with white matter fiber damage. The depression prediction model established has a certain accuracy in the diagnosis of adolescent depression. White matter fiber tract abnormalities may be the pathophysiological mechanism of depression and can be used as a potential biomarker for the diagnosis of depression.

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