Abstract #5055

Alteration in white matter tracts in early onset schizophrenia Using Diffusion tensor imaging

Mukesh Kumar¹, S Senthil Kumaran¹, Pankaj Pankaj¹, and Rajesh Sagar²

¹Dept. of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Department of psychiatry, All India Institute of Medical Sciences, New Delhi, India

Synopsis

Keywords: Psychiatric Disorders, Diffusion Tensor Imaging, Early-onset Schizophrenia

The study investigated white matter tracts disruption in early-onset Schizophrenia (EOS). Our finding revealed decreased white matter tracts fractional anisotropy (FA) and increased radial, axial and mean diffusivity in EOS as compared to controls, suggesting thinner packing of axon and fiber bundle. Disrupted white matter fibers may be associated with impaired neurobehavior in EOS.

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