Abstract #5056

Repeated Electroconvulsive Shock does not Affect Cognition and Neurometabolism in Mouse Brain

Ajay Sarawagi^1,2 and Anant Bahadur Patel^1,2

¹Department of NMR Microimaging and Spectroscopy, CSIR - Center for Cellular and Molecular Biology, Hyderabd, India, ²Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, India

Synopsis

Keywords: Psychiatric Disorders, Spectroscopy, Metabolism, Glutamate, GABA, 13C NMR

Electroconvulsive therapy is an effective treatment for chemo-resistant depression. The impact of electroconvulsive shock (ECS) on cognition and neurometabolism is not clear. The memory of mice was evaluated using Y-maze test. The rates of glucose oxidation (CMR_Glc(ox)) were measured by ¹H-[¹³C]-NMR spectroscopy together with an infusion of [1,6-¹³C₂]glucose after 24 hours and 3 months of the repeated ECS. The spontaneous alternation was decreased after 24 h and 1 month of repeated ECS, and was restored after two months. The CMR_Glc(ox) was reduced in PFC after 24 h of ECS. These changes were normalized after 3 months of ECS.

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