Abstract #5058

Myelination differences between cerebrum and cerebellum at early-stage schizophrenia detected by macromolecular proton fraction MRI.

Ekaterina Krupina¹, Andrei Valerievich Manzhurtsev^2,3,4, Maxim Vadimovich Ublinskiy^2,3, Olga Vasilievna Bozhko³, Galina Mamedova⁵, Vadim Ushakov^1,5,6, Natalia Zakharova⁵, Vasiliy Leonidovich Yarnykh^7,8, Denis Andreyuk⁵, Maxim Borisovich Shlyapnikov⁵, Georgiy Kostiuk⁵, and Tolib Abdullaevich Akhadov³

¹National Research Nuclear University MEPhI, Moscow, Russian Federation, ²Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation, ³Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation, ⁴Moscow State University, Moscow, Russian Federation, ⁵Psychiatric Clinical Hospital 1 named N.A. Alekseev., Moscow, Russian Federation, ⁶Institute for Advanced Brain Studies, Moscow State University, Moscow, Russian Federation, ⁷Radiology, University of Washington, Seattle, WA, United States, ⁸Laboratory of Neurobiology, Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russian Federation

Synopsis

Keywords: Psychiatric Disorders, Nervous system, myelin, schizophreniaThe purpose of this study is to identify quantitative alterations of the myelin content using the macromolecular proton fraction (MPF) method. Forty-five subjects, 22 controls and 23 schizophrenia patients participated in the study. A significant decrease in myelination in schizophrenia was observed in the left and right cerebral cortex and in the left and right cerebral white matter. No myelination alterations in the entire cerebellum (not separated into regions) were detected. The differences found in the regional and global myelination at an early stage of schizophrenia may provide additional information for understanding the biological mechanisms of the disease.

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