Abstract #5059

Obsessive-compulsive symptom-related brain connectivity associated with calcium homeostasis in first-episode drug-naïve schizophrenia

Qi Zhang¹, Hui Sun¹, Jiaxin Zeng¹, Xia Wei¹, Huaiqiang Sun¹, Naici Liu¹, Chengmin Yang¹, Wenjing Zhang¹, Jing Dai², Qiyong Gong¹, and Su Lui¹

¹Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China, ²The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders, schizophreniaThe present study recruited a Chinese Han cohort of first-episode patients with never-treated schizophrenia. Partial least squares regression was used to investigate the functional connectivity specifically related to obsessive-compulsive symptom and the results mainly involved the frontal lobe, insula, temporal lobe, and Rolandic operculum. Using association rules, we dug that Calcium level exhibited a bidirectional effect with the strength of the connection between the right Rolandic operculum and the right insula, especially regarding PCDHGB1 expression in the right Rolandic operculum.

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