Abstract #5060
In vivo primary sensorimotor cortex glutathione does not differ in autistic children
Yulu Song1,2, Kathleen E. Hupfeld1,2, Christopher W. Davies-Jenkins1,2, Helge Zöllner1,2, Deana Crocetti3, Steve C.N. Hui1,2, Vivek Yedavalli1, Georg Oeltzschner1,2, Natalie Alessi3, Mitchell A. Batschelett3, Nicolaas A.J. Puts4,5, Stewart H. Mostofsky3,6,7, and Richard A.E. Edden1,2
1The Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, United States, 4Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom, 5MRC Centre for Neurodevelopmental Disorders, King’s College London, London, United Kingdom, 6Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 7Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, United States
Synopsis
Keywords: Psychiatric Disorders, Spectroscopy, AutismRedox imbalance has been suggested as a pathophysiological factor in autism spectrum disorder (ASD). Edited MRS can be used to measure levels of glutathione, the most abundant redox compound in the brain. This study aims to compare glutathione levels in autistic children and typically developing children (TDC). Edited data were collected from the primary sensorimotor cortex (SM1) in 34 children with ASD and 31 TDC and quantified using Osprey. No difference was found in GSH levels in the SM1 between these two groups.
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