Keywords: Psychiatric Disorders, Brain, major depressive disorder
Major depressive disorder (MDD) showed both clinical symptoms and cognitive deficits. Prior studies have typically examined either symptoms or cognition correlated with brain measures, thus causing a paucity of stable brain markers that capture the full characteristics of MDD. Sparse canonical correlation analysis was used to assess the associations between two multi-dimensional clinical measurements (symptoms and cognition) and brain controllability of MDD. Average controllability of dorsal attention network (DAN) and visual network reached high associations with clinical variates in MDD, and altered controllability of DAN in patients could induce impairment of cognitive flexibility, and thus cause severe depressed mood.
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