Abstract #5084

Reproducibility of diffusion kurtosis parameters for a quantitative phantom in a multi-system study

Dariya Malyarenko¹, Scott D Swanson¹, Ramesh Paudyal², Amaresh Konar², Eddy Solomon³, Eric E Sigmund⁴, Stephen E Russek⁵, Sungheon Gene Kim³, Amita Shukla-Dave^2,6, and Thomas L Chenevert¹

¹Radiology, University of Michigan Health System, Ann Arbor, MI, United States, ²Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ³Radiology, MRI Research Institute, Weill Cornell Medical College, New York, NY, United States, ⁴Radiology, Center for Biomedical Imaging, NYU Langone Health, New York, NY, United States, ⁵National Institute of Standards and Technology, Boulder, CO, United States, ⁶Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

Synopsis

Keywords: Quantitative Imaging, Diffusion/other diffusion imaging techniques, diffusion kurtosis, multi-system reproducibility, quantitative phantomThis work studied reproducibility of apparent diffusion (D_a) and kurtosis (K_a) coefficients for three families of lamellar-vesicle materials in a quantitative phantom scanned at ambient temperature in a multi-site setting. Inter-system reproducibility of K_a was improved by maximum b-value fit-constraints for phantom materials with higher solid concentration, while temperature calibration improved D_a parameter consistency predominantly for materials with low solid concentration and containing longer-chain alcohols. After correction for temperature-dependence, these materials exhibited apparent diffusion reproducibility comparable to that of standard Gaussian diffusion controls.

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