Keywords: Quantitative Imaging, Challenges, Reproducibility
The longitudinal relaxation rate (R1) is deemed to be a suitable quantitative imaging metric for multi-site investigations as it describes a quantitative property of the tissue that can be measured, reproduced, and compared across sites when differences in hardware and acquisition settings are accounted for. Here, we present inter- and intra-vendor variability observed in whole-brain R1 maps generated from two-point inversion-recovery MRI data after accounting for variations in pulse sequences and B1+ field maps. We posit that this inter-site variability may be due to differential intensity scaling applied at acquisition and suggest a potential correction method using site-specific scaling factors.
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