Abstract #5088

Modeling and selection of T1 and T2 tissue mimics for 0.0065T, 0.064T, 0.55T MRI using agarose with manganese, gadolinium, copper, or nickel

Kalina V Jordanova¹, Ye Tian², Sheng Shen³, Michele N Martin¹, Megan E Poorman⁴, Rui Pedro Teixeira⁴, Krishna S Nayak², Matthew S Rosen^3,5, and Kathryn E Keenan¹

¹NIST: National Institute of Standards and Technology, Boulder, CO, United States, ²Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, ³Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ⁴Hyperfine, Inc., Guilford, CT, United States, ⁵Department of Physics, Harvard University, Cambridge, MA, United States

Synopsis

Keywords: Quantitative Imaging, Relaxometry

There is re-emerging interest in MRI fields ≤0.55T as well as quantitative MRI (qMRI) methods. Physiologically relevant reference objects are needed to adapt qMRI techniques to lower fields.

We investigate materials as tissue mimics for brain imaging at 0.0065T, 0.064T, 0.55T, for white matter, gray matter, fat, cerebrospinal fluid, and blood. We create samples composed of agarose and paramagnetic salts and measure relaxation across field strengths. Samples suitable to mimic each tissue are presented for each field strength. This work will facilitate qMRI development for fields ≤0.55T by providing accessible mimic compositions to the community.

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