Abstract #5092

Reproducibility of Whole-Body Variable Flip Angle T1 Mapping Using Only Two Flip Angles

Alistair Lamb¹, David Atkinson², Shonit Punwani², Hui Zhang³, and Anna Barnes⁴

¹Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, ²Centre for Medical Imaging, University College London, London, United Kingdom, ³Centre for Medical Image Computing, University College London, London, United Kingdom, ⁴King's Technology Evaluation Centre, King's College London, London, United Kingdom

Synopsis

Keywords: Quantitative Imaging, Whole Body, T1-mappingWe investigate the feasibility of whole-body (WB) variable flip angle (VFA) T1 mapping using linear least squares fitting with only two flip angles (FAs) in order to obtain WB T1 maps within a clinically viable timeframe. This could enable its use as an imaging biomarker in metastatic cancer. We assessed the agreement across eight subjects in a variety of abdominal tissues between T1 estimates fitted using eight FAs and just 2 FAs. We found that VFA T1 mapping can be achieved by acquiring only two FAs with minimal loss to precision, providing the lower FA is between 2.5° and 7.5°.

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