Abstract #5095

Multicenter and multi-vendor reproducibility of T1, T2 and ADC phantom data on 1.5T and 3T MRI scanners

Anna Caroli¹, Siria Pasini¹, Tau Vandelboe², Anish Raj^3,4, Leyre Garcia-Ruiz⁵, Anika Strittmatter^3,4, Rebeca Echeverria-Chasco⁵, Giulia Villa¹, Paolo Brambilla⁶, Esben Søvsø Szocska Hansen², Steffen Ringgaard², Frank G Zoellner^3,4, Maria Fernandez-Seara⁵, Susan Francis⁷, and Christoffer Laustsen²

¹Bioengineering Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica (BG), Italy, ²The MR Research Centre, Aarhus University, Aarhus, Denmark, ³Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ⁴Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ⁵Clínica Universidad de Navarra, Pamplona, Spain, ⁶Unit of Radiology, ASST Papa Giovanni XXIII, Bergamo, Italy, ⁷University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Quantitative Imaging, System Imperfections: Measurement & CorrectionThis multicentre study aimed at assessing multi-vendor accuracy and reproducibility of typical MR biomarkers on 3T and 1.5T scanners from 5 clinical centers. MRI acquisitions were performed using NIST protocols, on Essential System and Diffusion NIST phantoms. T1 was measured by 3-parameter fitting, while T2 and ADC by mono-exponential fitting, using PhantomViewer software. When compared with reference values, non-negligible discrepancies were found across vendors, especially for T1 and T2 measurements. Reproducibility was vendor-dependent, and higher on 3T than on 1.5T scanners. ADC and T1 showed highest reproducibility. Corrections are likely needed to account for possible temperature and scanner differences.

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