Abstract #5096

Longitudinal stability of brain and spinal cord structural quantitative MRI measures

Mathieu Boudreau¹, Agah Karakuzu¹, Arnaud Boré^2,3, Kiril Zelenkovski⁴, Basile Pinsard^2,3, Eva Alonso-Ortiz¹, Julie Boyle^2,3, Pierre Bellec^2,3,5, and Julien Cohen-Adad^1,3,6,7

¹NeuroPoly, Polytechnique Montreal, Montreal, QC, Canada, ²Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal (CRIUGM), Montreal, QC, Canada, ³Unité de Neuroimagerie Fonctionnelle (UNF), Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal (CRIUGM), Montreal, QC, Canada, ⁴Faculty of Computer Science and Engineering (FINKI), Skopje, Macedonia, ⁵Psychology Department, Université de Montréal, Montreal, QC, Canada, ⁶Mila - Quebec AI Institute, Montreal, QC, Canada, ⁷Centre de recherche du CHU Sainte-Justine, Université de Montréal, Montreal, QC, Canada

Synopsis

Keywords: Quantitative Imaging, Quantitative ImagingThe stability of quantitative MRI measures of microstructure in the brain and spinal cord was quantified longitudinally over three years. Six healthy subjects were scanned approximately four times per year with an structural quantitative imaging protocol (T1w, T2w, T2*w, DWI, MP2RAGE, MTsat, and B1). The intra-subject COV indicated good stability of all quantitative metrics measured in the brain (< 2.3% in WM, < 3.1% in GM). The spinal cord resulted in slightly higher COVs (3.9% - 9.5%). This work is part of a larger project, the Courtois project on neural modelling (CNeuroMod).

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