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Abstract #5102

Repeatability of Hyperpolarized Xenon-129 4D Imaging

Hooman Hamedani1, Stephen Kadlecek2, Faraz Amzajerdian2, Ryan Baron2, Kai Ruppert2, Mostafa Ismail2, Luis Loza2, Duncan Ian2, and Rahim Rizi2
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Quantitative Imaging, Lung, Hyperpolarized MRIIn order to image function in the free breathing lung with high temporal and special resolution, we have developed a methodology that can be used in combination with a non-rigid image registration technique to generate comprehensive quantitative maps of lung ventilation and gas exchange. For these HP MRI-derived regional parameters to produce meaningful information that can be used to characterize lung disorders, a reproducibility study that systematically assesses the variability of these parameters is needed. Here, we assess the reproducibility of our previously reported dynamic hyperpolarized imaging measurements between two sessions separated by minutes.

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