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Abstract #5104

Direct Imaging and T1 and T2* Quantification of Semi-Solid Red Blood Cell Membrane Lipid via Ultrashort Echo Time (UTE) Sequences

Soo Hyun Shin1, Dina Moazamian1, Arya Suprana1,2, Xiaojun Chen1, Jiyo S Athertya1, Chun Zeng1, Michael Carl3, Yajun Ma1, Hyungseok Jang1, and Jiang Du1,2,4
1Department of Radiology, University of California, San Diego, La Jolla, CA, United States, 2Department of Bioengineering, University of California, San Diego, La Jolla, CA, United States, 3GE Helathcare, San Diego, CA, United States, 4Radiology Service, Veterans Affairs San Diego Healthcare System, La Jolla, CA, United States

Synopsis

Keywords: Relaxometry, RelaxometryDirect imaging of semi-solid lipids, such as cell membranes and myelin, is of great interest. Yet, the short T2 of semi-solid lipid protons hampers direct detection through conventional pulse sequences. In this study, we examined whether an ultrashort echo time (UTE) sequence can directly acquire signals from membrane lipids. Cell membranes from red blood cells were subject to D2O exchange and freeze-drying for complete water removal. High MR signals were detected with the UTE sequence, which showed an ultrashort T2* of ~77-252 µs and a short T1 of 189 ms for semi-solid membrane lipids.

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