Abstract #5112

Quantification of Hemosiderin Deposition in Hemophilic Arthropathy Using Ultrashort Echo Time Quantitative Susceptibility Mapping (UTE-QSM)

Sam Sedaghat¹, James V Luck², Annette von Drygalski³, Scott T Ball⁴, Soo Hyun Shin¹, Eddie Fu¹, Eric Y Chang^1,5, Jiang Du^1,5,6, and Hyungseok Jang¹

¹Department of Radiology, University of California San Diego, San Diego, CA, United States, ²Department of Orthopaedic Surgery, University of California Los Angeles, Los Angeles, CA, United States, ³Department of Medicine, University of California San Diego, San Diego, CA, United States, ⁴Department of Orthopaedic Surgery, University of California San Diego, San Diego, CA, United States, ⁵Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States, ⁶Department of Bioengineering, University of California San Diego, San Diego, CA, United States

Synopsis

Keywords: MSK, HematologicWe investigated the quantitative capability of the UTE-QSM technique in the assessment of hemosiderin compared to histology. UTE-QSM and histology were performed in knee synovium tissues from hemophilia patients to visualize hemosiderin. The susceptibility maps from UTE-QSM showed a visually high similarity to the corresponding histological findings for all tissues. There was a significant difference in tissues with low and high iron load (p<0.001) in UTE-QSM. The susceptibility values on UTE-QSM showed a significant strong positive correlation to the blue signal in histology (R=0.908; p<0.001). We showed that UTE-QSM has excellent performance for detecting and quantifying hemosiderin in HA.

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