Abstract #5114

Robust assessment of macromolecular fraction in muscle with differing fat fraction using ultrashort echo time magnetization transfer modeling

Saeed Jerban¹, Yajun Ma¹, Qingbo Tang², Eddie Fu², Nikolaus Szeverenyi¹, Hyungseok Jang¹, Christine B Chung¹, Jiang Du¹, and Eric Y Chang^1,2

¹Radiology, University of California, San Diego, San Diego, CA, United States, ²Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, La Jolla, CA, USA, San Diego, CA, United States

Synopsis

Keywords: Muscle, Magnetization transfer, Collagen Content; Fat ContentMagnetization transfer (MT) MR imaging can indirectly characterize the spatial distribution of the relative contents of the macromolecular and water proton pools (MMF) of skeletal muscles. Fat presence in muscle has always been a source of concern in MMF calculation where some studies have reported significant underestimation of MMF for muscles with a considerable fat fraction (FF). We investigated the impact of FF on MMF in muscle/fat phantoms using an ultrashort echo time (UTE) MT model after T1 compensation. MMF demonstrated a relatively robust value with under 5% and 20% changes for FF increases up to 30 and 45%, respectively.

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