Abstract #5122

Validation of open-source minimal TE sequences across three independent sites

Gehua Tong¹, Andreia S. Gaspar², Rita G. Nunes², Jon-Fredrik Nielsen³, John Thomas Vaughan, Jr.^1,4, and Sairam Geethanath^4,5

¹Biomedical Engineering, Columbia University, New York, NY, United States, ²Institute for Systems and Robotics (ISR-Lisboa)/LaRSyS, Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal, ³Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, ⁴Columbia Magnetic Resonance Research Center, Columbia University, New York, NY, United States, ⁵Accessible MR Laboratory, BioMedical Engineering and Imaging Institute, Dept. of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mt. Sinai, New York, NY, United States

Synopsis

Keywords: Validation, Pulse Sequence DesignWe validated five open-source PyPulseq minimal TE sequences (half/full pulse 2D/3D UTEs and COncurrent Dephasing and Excitation (CODE)) at three sites with different scanner models. The ISMRM/NIST T₂ array and a porcine muscle and bone sample were imaged. SNR, contrast-to-noise ratio (CNR), and T₂ contrast curves were calculated and compared. We found that the sequences were able to recover more SNR from bone tissue compared to vendor GRE (an additional 50% - 1060% for 3T and 34% - 474% for 1.5T) and higher signal for short-T₂ spheres but intersite differences existed that were consistent with field strengths.

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