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Abstract #5140

Blind Source Separation Improves the Precision and Robustness of Self-Gated Motion Extraction in Free-Running 4D Whole-Heart MRI

Isabel Montón Quesada1, Augustin C. Ogier1, Jérôme Yerly1,2, Jonas Richiardi1, Christopher W. Roy1, Juerg Schwitter3, Matthias Stuber1,2, and Ruud B. van Heeswijk1
1Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2CIBM Center for BioMedical Imaging, Lausanne, Switzerland, 3Cardiology Service, Cardiovascular Department, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Synopsis

Keywords: Heart, Image ReconstructionSeveral cardiac and respiratory motion-resolved free-running acquisition techniques have recently been developed, but automated self-gated motion extraction with principal component analysis (PCA) alone remains challenging and sometimes fails to correctly identify the components related to cardiac motion. We combined three blind source separation algorithms (fastICA, ICASSO and SOBI) with PCA and compared them with gold-standard ECG R-wave triggers in 10 healthy volunteers to determine the most precise and robust self-gated cardiac trigger extraction. Of these tested techniques, PCA combined with SOBI resulted in the lowest variability of the cardiac intervals relative to ECG intervals (p=0.03) and the sharpest images (p=0.03).

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