Abstract #5144

The impact of multiple sclerosis on cortical brain stiffness.

Helge Herthum¹, Rafaela V. Silva², Anna S. Morr³, Mehrgan Shahryari³, Matthias Anders³, Yasmine Safraou³, Stefan Hetzer¹, Jürgen Braun³, Michael Scheel⁴, Friedemann Paul⁴, Carmen Infante-Duarte², and Ingolf Sack³

¹Berlin Center for Advanced Neuroimaging, Charité Universitätsmedizin Berlin, Berlin, Germany, ²Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, ³Department of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, ⁴Department of Neuroradiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

Synopsis

Keywords: Elastography, Brain, Cortical stiffnessMultiple sclerosis (MS) is a chronic neuroinflammatory disease that affects both white matter and cortical areas. While magnetic resonance imaging (MRI) can image pathological changes in the white matter, it is limited in quantifying cortical tissue damage in MS. Therefore, cerebral 3D-MR elastography based on multifrequency wave excitation and tomoelastography postprocessing was developed to measure cortical stiffness. We found that the cerebral cortex in MS patients is markedly softer than global brain matter and deep gray matter indicating the use of cerebral tomoelastography as a potential new imaging marker for monitoring MS disability.

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