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Abstract #5145

Testing the potential of DWI-based virtual elastography in patients with brain cancer

Siri Fløgstad Svensson1,2, Oliver Geier1, Elies Fuster-Garcia1,3, Gunnhild Ager-Wick1, Robin Anthony Birkeland Bugge1, Anne-Hilde Farstad4, Karoline Skogen5, and Kyrre Eeg Emblem1
1Department for Physics and Computational Radiology, Oslo University Hospital, Oslo, Norway, 2Department for Physics, University of Oslo, Oslo, Norway, 3Universitat Politècnica de València, BDSLab, Instituto Universitario de Tecnologías de la Información y Comunicaciones, València, Spain, 4Department for Radiography, Oslo University Hospital, Oslo, Norway, 5Department for Radiology, Oslo University Hospital, Oslo, Norway

Synopsis

Keywords: Elastography, ElastographyA previous study in the liver suggested that DWI can be used for virtual elastography. Here, we investigate the potential correlations between DWI-derived parameters and MR elastography (MRE) stiffness measurements in sixteen patients with brain cancer. The highest cross-correlation was obtained between stiffness and the shifted ADC map with b-values 1000 and 3000 s/mm² (median cross correlation 0.91). However, no correlation between mean values of MRE and sADC1000,3000 was found in normal-appearing white and gray matter, nor in tumor regions. This could be due to a too simple diffusion model and the anisotropic tissue structure of the brain.

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