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Abstract #5147

Characterization of Functional MR Elastography Responses to Variations in Visual Stimulus Frequency and Contrast

Harish Palnitkar1, Matthew C Murphy1, Yi Sui1, Kevin J Glaser1, Armando Manduca1, John Huston 3rd1, Richard L Ehman1, and Arvin Arani1
1Department of Radiology, Mayo Clinic, Rochester, MN, United States

Synopsis

Keywords: Elastography, Elastography, Functional MR ElastographyThe response of BOLD fMRI to changes in both visual contrast frequency and contrast intensity have been well documented. Recently, an increase in the stiffness of activated regions of the visual cortex due to a controlled variation of block duration has been demonstrated with fMRE elastograms. The current study aims to investigate the relationship between BOLD fMRI and fMRE due to a controlled variation of both contrast intensity and contrast frequency of a visual stimulation. This study demonstrates that the fMRE-measured stiffness change varies linearly with the underlying neural activity, which can be modulated by stimulus parameterization.

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