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Abstract #5148

A Biomechanical Analysis Framework for Co-Correlation of 7T MR Elastography Measures and Amyloid Beta Deposition

Emily Triolo1, Mackenzie Langan2,3, Oleksandr Khegai2, Akbar Alipour2, Carolina Ferreira-Atuesta3, Aymeric Pionteck1, Jonathan Sutkowski3, Trey Hedden3, Priti Balchandani2, and Mehmet Kurt1,2
1Mechanical Engineering, University of Washington, Seattle, WA, United States, 2Biomedical Engineering and Imaging Institute, Ichan School of Medicine at Mount Sinai, New York City, NY, United States, 3Graduate School of Biomedical Sciences, Ichan School of Medicine at Mount Sinai, New York City, NY, United States

Synopsis

Keywords: Elastography, Brain, 7T, Alzheimer's Disease, PETPrevious studies have implied the future use of MRE metrics to track disease progression and as a tool for AD diagnosis, potentially replacing or augmenting methods that use ionizing radiation. In this pilot study, we have therefore developed a novel framework for performing ultrahigh field (7T) MRE at high resolution on subjects who have previously undergone PET scans and performing joint analysis of biomechanical and pathologic markers on these subjects. We have successfully created a framework for measurement of high-resolution brain mechanical properties for co-correlation with traditional PET measures to be used on AD patients in the future.

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Keywords