Abstract #5157

Quantifying inhomogeneity of kidney, liver and muscle before and after the freeze-thaw cycle using 1-Norm waveform analysis and MR elastography

Rolf Reiter^1,2, Harish Palnitkar³, Shreyan Majumdar⁴, Joseph Crutison⁴, Shujun Lin⁴, Thomas J. Royston⁴, and Dieter Klatt⁴

¹Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²BIH Biomedical Innovation Academy, BIH Charité Digital Clinician Scientist Program, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany, ³Radiology, Mayo Clinic, Rochester, MN, United States, ⁴Richard and Loan Hill Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL, United States

Synopsis

Keywords: Elastography, Tissue Characterization

The recently developed 1-Norm technique can be used to quantify the extend of scattering of mechanical waves generated by inhomogeneities. This explorative study shows that 1-Norm can detect mechanical inhomogeneity of ex vivo kidney, liver and muscle without the need to use ill-posed wave inversion techniques. The 1-Norm technique has potential to serve as an MRE-based diagnostic biomarker independent of stiffness for the characterization of pathological conditions associated with changes in tissue mechanical inhomogeneity.

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