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Abstract #5159

MRE navigator for rapid estimation of liver stiffness.

Matthias Anders1, Carsten Warmuth1, Josef Pfeuffer2, Heiko Tzschätzsch1, Helge Herthum1, Katja Degenhardt3, Oliver Wieben4, Sebastian Schmitter3, Jeanette Schulz-Menger1,5,6, Jürgen Braun1, and Ingolf Sack1
1Charité - Universitätsmedizin Berlin, Berlin, Germany, 2MR Application Development, Siemens Healthcare, Erlangen, Germany, 3Physikalisch-Technische Bundesanstalt(PTB), Braunschweig and Berlin, Berlin, Germany, 4University of Wisconsin, Madison, WI, United States, 5Experimental and Clinical Research Center (ECRC), DZHK partner site Berlin, Berlin, Germany, 6HELIOS Klinikum Berlin Buch, Berlin, Germany

Synopsis

Keywords: Elastography, Data AcquisitionMR elastography (MRE) can noninvasively detect liver fibrosis based on elevated stiffness values. However, a complete MRE scan is time-consuming and typically extends over multiple breath-holds. Therefore, a multi-shot gradient echo sequence with spiral readout was developed to provide full two-dimensional elastograms of the liver in less than one second. The new sequence can be used as an MRE navigator to provide immediate feedback on wave penetration and data consistency for parameter optimization prior to running full multi-dimensional MRE. Moreover, the method can be used to rapidly track potential changes in liver stiffness such as those induced by respiration.

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