Abstract #5166

Brain water-content based Electrical Properties Tomography in healthy volunteers, tumor and multiple sclerosis patients

Stefano Mandija^1,2, Sarah Jacobs³, Jordi Kleinloog^1,2, Hongyan Liu^1,2, Oscar van der Heide^1,2, Anja van der Kolk^1,4, Alessandro Sbrizzi^1,2, and Cornelis van den Berg^1,2

¹Department of Radiotherapy, UMC Utrecht, Utrecht, Netherlands, ²Computational Imaging Group for MR Therapy and Diagnostics, UMC Utrecht, Utrecht, Netherlands, ³Department of Radiology, UMC Utrecht, Utrecht, Netherlands, ⁴Department of Medical Imaging, Radboud UMC, Nijmegen, Netherlands

Synopsis

Keywords: Electromagnetic Tissue Properties, Electromagnetic Tissue Properties, ConductivityIn this work, we first extend the validation of the water-content based Electrical Properties Tomography (wEPT) model from brain white matter to gray matter conductivity reconstructions in healthy volunteers. Secondly, we show that wEPT reconstructions calibrated on 10 healthy volunteers from an MR-STAT clinical trial dataset show a conductivity increase in pathological regions for 6 primary brain tumor and 9 multiple sclerosis (MS) patients from the same study. For diffuse glioma, a positive correlation between grade and conductivity is observed. For MS white matter lesions a clear conductivity increase is observed compared to healthy white matter.

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