Abstract #5169

Determination of optimal parameters for accelerated whole-body diffusion-weighted imaging (WB-DWI) using simultaneous multi-slice (SMS)

Sam Keaveney^1,2, Alina Dragan¹, Julie Hughes¹, Mihaela Rata^1,2, Thomas Benkert³, Christina Messiou^1,2, Dow-Mu Koh^1,2, and Jessica M Winfield^1,2

¹MRI Unit, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom, ²Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom, ³MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, Whole Body, Simultaneous Multi-Slice

Simultaneous multi-slice (SMS) has the potential to accelerate whole-body diffusion-weighted imaging (WB-DWI). This work presents quantitative and qualitative assessment of SMS image quality in phantoms and healthy volunteers, as a strategy to determine the optimal parameters for the clinical application of a research application SMS sequence.

An SMS factor of 2 and a moderately reduced TR did not introduce significant bias to ADC measurements. The reduction in SNR for these acquisitions was statistically, but not clinically, significant. These parameters offer time savings of up to 24% with respect to non-SMS settings and should be investigated further in a patient population.

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