Keywords: Diffusion/other diffusion imaging techniques, RadiotherapyDiffusion weighted imaging (DWI) allows for the evaluation of tumor cellularity. Its application on a 0.35 T MRI-guided linear accelerator (MRL) would facilitate integration of this information into radiotherapy planning and potentially allow for online biologically-guided plan adaption. This study demonstrates the capability of a DWI protocol both in phantom and in vivo. In particular, it is demonstrated that quantitively accurate, repeatable, and geometrically precise ADC maps can be produced in phantom on the 0.35 T MRL. Additionally, this technique was applied in vivo on one sarcoma patient receiving same-day diagnostic diffusion scans before, during, and after radiotherapy.
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