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Abstract #5174

Diffusion imaging on a 0.35 T MRI-guided linear accelerator providing accurate ­in vivo ­apparent diffusion coefficient maps

Joseph Weygand1, Tess Armstrong2, J.M. Bryant1, Jacqueline Andreozzi1, Ibrahim M. Oraiqat1, Casey L. Liveringhouse1, Kujtim Latifi1, Kosj Yamoah1, James R. Costello3, Eduardo G. Moros1, Issam M. El Naqa4, Arash O. Naghavi1, Stephen A. Rosenberg1, and Gage Redler1
1Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, United States, 2Department of Product Development, ViewRay, Oakwood Village, OH, United States, 3Department of Radiology, Moffitt Cancer Center, Tampa, FL, United States, 4Department of Machine Learning, Moffitt Cancer Center, Tampa, FL, United States

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, RadiotherapyDiffusion weighted imaging (DWI) allows for the evaluation of tumor cellularity. Its application on a 0.35 T MRI-guided linear accelerator (MRL) would facilitate integration of this information into radiotherapy planning and potentially allow for online biologically-guided plan adaption. This study demonstrates the capability of a DWI protocol both in phantom and in vivo. In particular, it is demonstrated that quantitively accurate, repeatable, and geometrically precise ADC maps can be produced in phantom on the 0.35 T MRL. Additionally, this technique was applied in vivo on one sarcoma patient receiving same-day diagnostic diffusion scans before, during, and after radiotherapy.

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Keywords