Abstract #5175

Integrating intravoxel incoherent motion and diffusion tensor MRI of the brain into a single fast acquisition - a model-selection study

Olaf Dietrich¹, Mengfei Cai², Anil Tuladhar², Mina Jacob², Gerald Drenthen³, Jacobus Jansen^3,4, José Marques², Jens Ricke¹, Frank-Erik de Leeuw², Marco Duering⁵, and Walter Backes³

¹Department of Radiology, LMU University of Munich, Munich, Germany, ²Department of Neurology, Donders Center for Medical Neurosciences, Radboud University Medical Center, Nijmegen, Netherlands, ³Schools for Mental Health and Neuroscience (MHeNs) and Cardiovascular Diseases (CARIM), Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ⁵Medical Image Analysis Center (MIAC AG) and qbig, Department of Biomedical Engineering, University of Basel, Basel, Switzerland

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, Diffusion Tensor Imaging, Intravoxel incoherent motion MRI; Model selection; Brain; Cerebral small vessel diseaseThe acquisition of IVIM and DTI data of the brain can be integrated into a single measurement, which offers the possibility to determine orientation-dependent (tensorial) perfusion parameters in addition to established IVIM and DTI parameters. The purpose of this study was to evaluate the feasibility of such an integrated IVIM-DTI protocol with a clinically feasible scan time below 6 minutes and to establish the maximum number of DTI and IVIM tensor parameters that can reliably be determined with this approach by comparing 17 different IVIM-diffusion models with 4 to 19 model parameters.

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