Keywords: Diffusion/other diffusion imaging techniques, Diffusion Tensor Imaging, Cancer, Fractional Anisotropy, DWI, ADC
In previous studies average values of Apparent Diffusion Coefficient (ADC) have been shown to change significantly after radiotherapy in Soft-Tissue Sarcomas (STS). In this study we evaluate the Fractional Anisotropy (FA) of STS before and after treatment and demonstrate that (i) tumours can exhibit significant diffusion anisotropy, and (ii) changes in FA are inversely correlated with ADC change. Diffusion-Tensor Imaging (DTI) may therefore provide important microstructural information when interpreting change in STS after radiotherapy, and that diffusion anisotropy should be accounted for when optimising diffusion-weighted imaging (DWI) protocols for STS.
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