Abstract #5178

Time-dependence of perfusion fraction with flow-compensated intravoxel incoherent motion MRI in the brain

Louise Rosenqvist¹, Mikael Montelius¹, Maria Ljungberg^1,2, and Oscar Jalnefjord^1,2

¹Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ²Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, Perfusion, IVIM

Using IVIM imaging for completely non-invasive perfusion MRI is gaining popularity. IVIM perfusion assessment depends not only on capillary network characteristics, but also on diffusion encoding-time. In this study, a flow-compensated pulse sequence with variable encoding-time was implemented and validated through phantom measurements, and subsequently used to study the encoding-time dependence of IVIM perfusion fraction in human brain tissue. Initial findings indicate a decrease in perfusion fraction as encoding-time increases.

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