Abstract #5200

N-acetylaspartate and myo-inositol provide complementary information for lateralization of mesial temporal lobe epilepsy

Hui Huang¹, Miao Zhang², Bingyang Cai¹, Siyu Yuan¹, Wen Jin^3,4, Yudu Li^3,5, Yibo Zhao^3,4, Zhi-Pei Liang^3,4, Yao Li¹, Biao Li², and Jie Luo¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Beckman Institute for Advanced Sciences and Technology, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁴Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁵National Center for Supercomputing Applications, University of Illinois at Urbana Champaign, Urbana, IL, United States

Synopsis

Keywords: Epilepsy, MetabolismLateralization of drug refractory mesial temporal lobe epilepsy can be challenging for routine MR scans at 3.0T. Exogenous and radioactive tracer¹⁸F-FDG has been widely reported to aid the lateralization of MR unidentifiable epileptic hippocampus. ¹H-MRSI holds promise to provide endogenous metabolic information of the epileptogenic zone. This study demonstrated the feasibility of fast high-resolution mapping of NAA/Cr, mIn/Cr and mIn/NAA, and investigated their associations with the FDG uptake. Our experimental results showed that NAA and mIn were independently sensitive to metabolic changes in hippocampal sclerosis, providing complementary information for temporal lobe epilepsy lateralization.

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