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Abstract #5207

Diffusion spectrum imaging study of cognitive and emotional related structural network in patients with temporal lobe epilepsy

jiachen Li1, jing Zhang1, wanjun Hu1, guangyao Liu1, liang Zhou1, and kai Ai2
1Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, 2Philips Healthcare, Xi'an, China

Synopsis

Keywords: Epilepsy, Diffusion/other diffusion imaging techniquesTo investigate the relationship between changes in brain networks and changes in emotion and cognition in patients with temporal lobe epilepsy. We used Diffusion spectrum imaging to construct structural brain networks. Then graph-theoretical analysis was applied to estimate structural connectivity and network properties in temporal lobe epilepsy (TLE) patients. Our study found that the brain network connectivity is altered and this alteration is associated with cognitive decline in TLE patients. This result offers a complementary understanding of neuropathology mechanism of TLE and its related cognition alteration, which may be helpful for clinical diagnosis and prognosis evaluation.

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