Keywords: Epilepsy, Diffusion/other diffusion imaging techniquesTo investigate the relationship between changes in brain networks and changes in emotion and cognition in patients with temporal lobe epilepsy. We used Diffusion spectrum imaging to construct structural brain networks. Then graph-theoretical analysis was applied to estimate structural connectivity and network properties in temporal lobe epilepsy (TLE) patients. Our study found that the brain network connectivity is altered and this alteration is associated with cognitive decline in TLE patients. This result offers a complementary understanding of neuropathology mechanism of TLE and its related cognition alteration, which may be helpful for clinical diagnosis and prognosis evaluation.
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