Keywords: Epilepsy, Arterial spin labellingOlder adults with epilepsy accompanied by cognitive impairment represent a huge proportion, which calls for novel clinical techniques for early diagnosis and intervention. By applying pseudo-continuous arterial spin labeling (PCASL), we identified whole-brain voxel-based perfusion pattern of epilepsy associated with cognitive impairment, and explored correlations between cerebral blood flow (CBF) and domain-specific cognitive performance. The enrolled patients exhibited decreased CBF mostly in the bilateral frontal lobes, and there were positive associations between mean CBF and memory as well as executive function. Therefore, CBF measured by PCASL may be a useful indicator for cognitive performance in older adults with MRI-negative epilepsy.
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