Keywords: Epilepsy, fMRI (resting state)Combining structural and functional neuroimaging analyses with brain transcriptional data, the present study investigated GMV and fALFF changes in children with RE as well as their underlying gene transcriptional profiles. VBM and fALFF analyses showed altered GMV and fALFF in brain regions associated with behavioral and cognitive regulation. Transcription-neuroimaging spatial correlation analyses further identified genes correlated with GMV and fALFF changes in RE, respectively. Moreover, functional enrichment analysis demonstrated that RE-related genes were enriched for the regulation of biological process. These findings may provide us with important knowledge for understanding the pathophysiological basis of this disease.
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