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Abstract #5234

Hydroxyethylcellulose as a tissue mimicking phantom gel: Characterizing the temperature response at 0.5T

Diego F Martinez1, Curtis N. Wiens2, Chad T. Harris2, Will B. Handler1, and Blaine A. Chronik1,3
1The xMR Labs, Physics and Astronomy, Western University, London, ON, Canada, 2Research and Development, Synaptive Medical, Toronto, ON, Canada, 3Medical BioPhysics, Western University, London, ON, Canada

Synopsis

Keywords: Phantoms, ThermometryTemperature Mapping at 0.5T offers an accessible method for non-invasively tracking thermal procedures, relying on tissue temperature response of properties such as Proton Resonant Frequency, Apparent Diffusion Coefficient, or T1. To evaluate performance of temperature mapping using these properties, Hydroxyethyl Cellulose – a tissue mimicking gel – was formulated using the ISO 10974:2018 standard and doped with CuSO4 to match representative tissue T1 values. Temperature response of each of these parameters was: PRF parameter α= (-8.74 ± 0.12) x 10-3 ppm/°C, T1 parameter (12.02 ± 0.07) ms/°C, and ADC parameter (5.34 ± 0.063) x 10-5 mm2/s/°C, all in acceptable range.

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