Abstract #5237

Development of an MR-Compatible Motion Phantom to Evaluate Motion-Robust Quantitative MRI

Jiayi Tang^1,2, James Rice^2,3, Jack Gwertzman³, Scott B. Reeder^1,2,4,5,6, Alejandro Roldán-Alzate^2,3, and Diego Hernando^1,2

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Phantoms, Motion Correction

Chemical-shift encoded (CSE) MRI can quantify PDFF and R2* as biomarkers for liver fat and iron deposition, respectively, but conventional methods (3D-CSE) are not motion-robust. Recent methods (2D-CSE-FAM) have been proposed which demonstrate motion-robustness; the evaluation of these methods urges the development of a MR-compatible motion phantom. In this work, we constructed such a phantom, validated it via video tracking, and used it to show motion artifacts and quantification biases in 3D-CSE, identify a potential source of bias in axial R2* 2D-CSE-FAM acquisitions, and confirm the motion-robustness of coronal 2D-CSE-FAM.

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