Keywords: Phantoms, Diffusion/other diffusion imaging techniques, Cell Mimics, Polymerized SpheresIn order to verify modern diffusion MRI sequences, a well-defined reference system consisting of polymerized, hollow microspheres with a hole in the surface is synthesized. This reference system can model the diffusion properties of cells with varying size1,3 and membrane permeability2. To produce these cell mimics3, tripropyleneglycol-monomethylether monomer was mixed with an ammonia solution with polystyrene particles to initiate a nucleation process. The droplets were inflated in an NaOH solution and then hardened under UV exposure. Lastly, the polystyrene particles were dissolved. Scanning Electron Microscope images and DWI measurements were acquired to verify the quality of the cell mimics.
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