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Abstract #5240

Rapid Luminescence Quantification of a Sensitized Gadolinium Based Contrast Agent

James A. Tranos1, Ayesha Das2, Jin Zhang2, Sonia Hafeez1, Suleiman Khan1, Neelam Pandya1, Sungheon Gene Kim2, and Youssef Zaim Wadghiri1
1Radiology, NYU Grossman School of Medicine, New York, NY, United States, 2Radiology, Weill Cornell Medicine, New York, NY, United States

Synopsis

Keywords: Contrast Agent, Preclinical, Gadolinium Based Contrast Agent, Luminescence Quantification, Plasma Clearance KineticsGadolinium based contrast agents (GBCA) are widely used in magnetic resonance imaging and are paramount to cancer diagnostics. Furthermore, accurate quantification of gadolinium in blood/plasma (clinical media) is essential to tumor pharmacokinetic analysis, with current methods being low throughput and clinically unavailable. As such, we have developed a simple luminescence quantification assay to measure the concentration of gadolinium in clinical media using a sensitized GBCA referred to as Gd[DTPA-cs124]. Here, we demonstrate the efficacy, increased relaxivity and enhanced biocompatibility of our agent when compared to other GBCA’s, as well as its ability to model pharmacokinetic clearance in a mouse model.

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