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Abstract #5250

Comparing 129Xe gas MRI across major MRI vendors and sites

Asu Rolland1,2, Matthew M Willmering1, Zackary I Cleveland1, Andrew D Hahn3,4, Sean B Fain3,4, Jaime F Mata5, John P Mugler5, Bastiaan Driehaus6, and Jason C Woods1,7
1Pulmonary Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Physics, University of Cincinnati, Cincinnati, OH, United States, 3University of Iowa, Iowa City, IA, United States, 4University of Wisconsin, Madison, WI, United States, 5University of Virginia, Charlottesville, VA, United States, 6Duke University, Durham, NC, United States, 7University of Cincinnati, Cincinnati, OH, United States

Synopsis

Keywords: Data Acquisition, Quantitative ImagingMulti-site studies and clinical hyperpolarized 129Xe are imminent, yet image quality is challenging to quantify across MR platforms since hardware, gradient-corrections, and data-filtering are proprietary. We developed a straightforward protocol for scanning a commercial, thermally-polarized 129Xe phantom, and implemented it across three major MRI vendors, with near-identical coils. Images were acquired at 5 sites (Cincinnati, Iowa, Wisconsin, Duke, and Virginia). SNR was 18.4±1.6, with low variation in SNR between sites (13%), and vendors (10%). This confirms the ability to quantitatively compare signal and noise across sites and vendors. It is also demonstrated, here, that quality control can be implemented simply in multi-site studies.

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