Abstract #5264

Reliable Glutamate Measurements at 3T: Which Sequence should I Choose?

Philip F. Durham¹, Humberto Monsivais¹, Gianna Nossa¹, Daniel Foti², Xiaopeng Zhou³, and Ulrike Dydak^1,4

¹College of Health and Human Sciences, Purdue University, West Lafayette, IN, United States, ²Department of Psychological Sciences, Purdue University, West Lafayette, IN, United States, ³Purdue Life Sciences MRI Facility, Purdue University, West Lafayette, IN, United States, ⁴Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

Synopsis

Keywords: Data Acquisition, Brain, Glutamate, MRSThis meta-analysis discusses the intra- and inter-subject variability of glutamate measurements in MRS, comparing widely used sequences on clinical scanners (PRESS, sLASER, MEGA-PRESS, MEGA-sLASER, HERMES). To minimize variance in glutamate measurements, the authors recommend sLASER over PRESS, non-edited over edited MRS, and OFF over DIFF spectra.

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