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Abstract #5270

Neuroimaging Correlates of Functional Motor Changes in Cognitively Impaired Cohorts

Maurizio Bergamino1, Elizabeth G Keeling1,2, Sydney Y Schaefer2, Anna Burke1, George Prigatano1, and Ashley M Stokes1
1Barrow Neurological Institute, Phoenix, AZ, United States, 2Arizona State University, Tempe, AZ, United States

Synopsis

Keywords: Data Analysis, Diffusion/other diffusion imaging techniquesThe objective of this study was to assess white matter microstructural differences between groups of healthy controls (HC), subjective memory complaints (SMC), and cognitive impairment (CI) through multi-shell free-water (FW) corrected DTI (FW-DTI) metrics and by the peak width of skeletonized mean diffusivity (PSMD). Additionally, brain correlations at the voxel level between a functional motor measure (two-bean transfer) and DTI metrics/PSMD were explored.

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Keywords