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Abstract #5282

Demonstration of Distinct Iron Deposition Patterns in Gliomas using 7T Quantitative Susceptibility Mapping

Demetrius Eugene Lee, B.S.1,2, Kristina Vineis, B.S.1,2, Laiz Godoy, M.D.1,2, Lisa Desiderio, RT (R)(MR)1,2, Suyash Mohan, M.D.1,2, and Sanjeev Chawla, Ph.D1,2
1Radiology, Perelman School of Medicine, Philadelphia, PA, United States, 2University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Tumors, Blood vessels, Glioma

Evidence has shown that abnormal iron levels and gliomas are heavily correlated. Due to this, iron presents a possibility to serve as a glioma biomarker. This study will utilize susceptibility-weighted imaging (SWI) to identify the glioma, and quantitative susceptibility mapping (QSM) to explicitly classify iron deposits in the glioma on an ultra-high field (7T) scanner.

A total of 6 untreated glioma patients with high- and low-grade gliomas underwent 7T QSM. Patients with high-grade gliomas showed distinct, geometric iron deposits that low-grade gliomas did not. These results illustrate that 7T QSM may be helpful in classifying low- and high-grade gliomas.

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