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Abstract #5283

Differences in vascularity between recurrent glioblastoma and brain metastasis using dynamic contrast enhanced MRI

Sapir Fajerzstein1,2,3, Moran Artzi1,3,4, Deborah T. Blumenthal4,5, Dror Limon4,6, Orna Aizenstein7, Felix Bokestein4,5, Netanell Avisdris1, and Dafna Ben, Bashat1,3,4
1Sagol Brain Institute, Tel Aviv Sourasky Medical Center (TASMC), Tel Aviv, Israel, 2The Iby and Aladar Fleischman Faculty of Engineering TAU, Tel Aviv, Israel, 3Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, 4Sackler Faculty of Medicine, Tel Aviv University (TAU), Tel Aviv, Israel, 5Division of Oncology, TASMC, Tel Aviv, Israel, 6Neuro-Oncology Service, TASMC, Tel Aviv, Israel, 7Division of Radiology, TASMC, Tel Aviv, Israel

Synopsis

Keywords: Tumors, DSC & DCE PerfusionHigh grade glioma (HGG) and brain-metastasis are known to have different vascularity. Dynamic contrast-enhanced (DCE) was suggested to assess disease progression, and to differentiate between tumor recurrence and radiation necrosis. However, previous methods did not relate to the differences in vascularity of the two tumor types and often offer the same method and same threshold values. We show differences between groups with: higher vascularity, slightly increased permeability, higher percent of arteries overlapping of the tumor, and differences in several radiomics features, in recurrent HGG compared with recurrent brain-metastasis. Future studies should relate to these differences between the two tumor types.

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